089 Suppressive effect of HMGB1 via poly (I:C) induced inflammation in keratinocyte

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

Silica-Induced Pulmonary Inflammation Suppressive Oligodeoxynucleotides Inhibit

ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression

Lipopolysaccharide (LPS) triggers innate immunity mainly via TLR4 signaling. ATF3 is a negative regulator of TLR4 signaling. HMGB1 plays a critical role in the final step of sepsis. However, the mechanisms of ATF3 and the role of HMGB1 in regulating innate immunity-induced sepsis are incompletely understood. In this study, we found that serum HMGB1 levels were 10-fold higher in patients with se...

Suppressive effect of zinc on some functions of neutrophils: studies with carrageenan-induced inflammation in rats.

The effect of zinc administration to rats on the acute inflammatory response to carrageenan in the pleural cavity was studied. The number of neutrophils mobilized into the pleural cavity was markedly reduced in a dose-dependent manner, whereas the volume of exudate formed significantly increased during the development of pleurisy. In the neutrophils isolated from zinc-treated rats, the mobiliza...

Curcumin Alleviates Streptozotocin-Induced Hyperalgesia in Diabetic Neuropathic Rat via Attenuation of Lipid Peroxidation and Inflammation

Background and Objective: Hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. This study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (STZ)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. Materials and Methods: This study was conducted on 40 male...